Found 1431 clinical trials
A Study to Evaluate the Safety and Tolerability of Venetoclax Tablets in Combination With Capecitabine Tablets in Adult Participants With Hormone Receptor-Positive HER2-Negative Locally Advanced or Metastatic Breast Cancer Who Had Disease Progression During or After CDK4/6 Inhibitor Therapy
During dose escalation, participants will take various doses of venetoclax as a tablet by mouth once a day and capecitabine as a tablet by mouth twice per day on days 1 - 14 of each cycle for approximately 30 weeks.
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- 16 Feb, 2024
- 16 locations
Resting Full-cycle Flow Ratio (RFR) Versus Angiography to Guide Revascularization Strategy in Patients Undergoing Coronary Artery By-pass Grafting (CABG)
Differently from FFR which is a measurement performed in maximal hyperemia, the RFR is a measurement that is performed in rest and therefore may predict better than FFR the baseline equilibriums that could lead to graft failure, while it has similar capacity to identify hemodynamically significant stenosis as FFR. It …
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- 05 Aug, 2020
A Feasibility Study on Ultrafiltration and Blood Volume Measurements
The objective of this feasibility study is to characterize the performance of CHF Solutions' ultrafiltration system, the Aquadex FlexFlow System with the hematocrit (HCT) feature in conjunction with Daxor's blood volume analyzer (BVA-100). Monitor blood volume changes during UF therapy as a potential mean to guide the removal of fluid …
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- 16 Feb, 2024
- 1 location
Tolerability Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron Disease
Non-invasive mechanical ventilation (NIMV) is the recommended standard of care as initial therapy for patients with motor neuron disease (MND) with deterioration of the respiratory function. SIGH_01 study is aimed at investigating the tolerability, safety profile and efficacy of sigh breaths during non-invasive mechanical ventilation in patients with MND in …
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- 16 Feb, 2024
- 1 location
Ginko Biloba Versus Desmopressin in Treatment of Children With Monosymptomatic Nocturnal Enuresis
While one of theory of nocturnal enuresis is deep sleep in children , this the main cornerstone in using Alarm as line of management .On the other hand drugs used in rehabitation of sleep rhythm seems to be with great benefits in management as GINKO BILOBA Ginkgo biloba leave extract …
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- 07 Apr, 2025
Taiwan "Aerosol Box" Versus UMMC "Intubation Box"
Anaesthetists with more than 5 years of clinical experience in intubating airways as well as more than 20 successful intubations using videolaryngoscopy , will be available to participate. This study will employ manikin and will be a randomized cross-over trial, conducted in UM.
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- 05 Aug, 2020
Progressive Resistance Training for Sarcoma Survivors
This trial studies how well progressive resistance training works in improving the physical function of sarcoma survivors. Treatments for sarcoma can cause side effects such as fatigue, muscle loss, and weakness, which can negatively impact a patient's ability to physically function and enjoy an independent lifestyle.
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- 16 Feb, 2024
- 1 location
A Phase I/Ib Study of NIZ985 Alone and in Combination With Spartalizumab
Moreover, the study will characterize the pharmacokinetic profiles of NIZ985 as a single agent and in combination with Spartalizumab and identify preliminary anti-tumor activity.
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- 16 Feb, 2024
- 1 location
CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old
This phase II trial studies how well liposome-encapsulated daunorubicin-cytarabine (CPX-351) works in treating patients with secondary acute myeloid leukemia who are younger than 60 years old. Drugs used in chemotherapy, such as CPX-351, work in different ways to stop the growth of cancer cells, either by killing the cells, by …
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- 16 Feb, 2024
- 1 location
Organ Preservation Program Using Short-Course Radiation & FOLFOXIRI in Rectal Cancer
The objective is to learn if this treatment approach may safely be used as an alternative to the standard treatment for rectal cancer and to know the quality-of-life in these patients.
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- 16 Feb, 2024
- 1 location