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Found 3,739 clinical trials

B Briohny Johnston

A Study of TTYP01 in Healthy Adult Subjects

This is integrated Phase 1, Single centre, Randomized study will be conducted in 3 parts, each with a specific primary objective: Part A: To characterise the safety and tolerability of TTYP01 in healthy adult subjects; Part B: To evaluate the bioavailability of TTYP01 tablets in healthy adult subjects; Part C: …

18-40 years All Phase 1
A Anh Hai Nguyen, MD, PhD

Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Chronic Obstructive Pulmonary Disease

To evaluate the safety and efficacy of human umbilical cord mesenchymal stem cells transplantation in patients with COPD

40 years and older All Phase 1/2
R Ronald Theodore, MS

A Trial to Evaluate Safety and Tolerability of TST001 in Advanced or Metastatic Solid Tumors

This is an open label Phase 1, First in Human trial of TST001, a recombinant humanized anti-Claudin 18.2 (CLDN18.2) IgG1 monoclonal antibody. It is being tested against advanced and/or metastatic solid tumors including gastric, gastroesophageal junction, pancreatic, colon and lung cancers.

18 years and older All Phase 1
S Sangmi Lee

This is a Study to Evaluate the Safety and Tolerability of the Study Medication ABL001 in Combiation With Irinotecan/Paclitaxel and to Determine the Maximum Tolerated Dose and/or Recommended Phase 2 Study Dose of ABL001 in Combination With Irinotecan/Paclitaxel.

The purpose of this open-label, combination dose escalation, Phase 1b/2a clinical trial is to evaluate the safety, pharmacokinetics and anti-tumor activity and determine the maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of combination therapy with ABL001(NOV1501) and Paclitaxel/Irinotecan .

19 years and older All Phase 1/2
Q Quanren Wang, phD

A Trial of SHR-1802 in Patients With Failure of Standard Treatment for Advanced Malignant Tumours

This is the first study to test SHR-1802 in humans. The primary purpose of this study is to see if SHR-1802 is safe and tolerable for patients with locally advanced/unresectable or metastatic malignancies that are refractory to available therapy or for which no standard therapy is available.

18-75 years All Phase 1
L Laura J. Szewczyk

COVID-19 First In Human Study to Evaluate Safety Tolerability and Pharmacokinetics of EIDD-2801 in Healthy Volunteers

This is a First In Human study designed to assess the safety, tolerability and pharmacokinetics of EIDD-2801 in healthy human volunteers.

18-60 years All Phase 1
Y Yuka Uenohara

Multiple Dose Escalation Study of M201-A in Healthy Japanese Subjects

This Phase I is designed to evaluate the safety, tolerability and pharmacokinetics of multiple ascending doses of M201-A administered by multiple continuous intravenous injection in Healthy Japanese subjects.

20-49 years Male Phase 1
Y Yves Beguin, MD,PhD

Mesenchymal Stromal Cell Therapy for Severe Covid-19 Infection

The overall objective of the study is to evaluate the safety and efficacy of MSC therapy combined with best supportive care in hospitalized patients with COVID-19.

18-70 years All Phase 1/2
F Fuming Qiu, PhD

Neoadjuvant of Sintilimab Combined With Chemotherapy for Resectable NSCLC neoSCORE

This is a Phase 2, prospective, randomized, open-Label, single-center international study that assesses the efficacy and safety of neoadjuvant therapy with different cycles of sintilimab combined with chemotherapy for resectable NSCLC. This trial will also explore the biomarkers of neoadjuvant immunochemotherapy.

18-75 years All Phase 2
S Sheng-Mou Hsiao, M.D.

Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy Psychological Distress Sexual Function Urethral and Bladder Wall Structure and Blood Flow in Women With Stress Urinary Incontinence: a Randomized Controlled Study

To assess the impact of Duloxetine and Imipramine on therapeutic efficacy, psychological distress, sexual function, bladder wall structure and blood flow in women

25 years and older Female Phase 3

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