Found 3,739 clinical trials
Effects of Brain Stimulation on Cognition Oscillations and GABA Levels in Schizophrenia
The purpose of this study is to use a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), to test a set of hypotheses about the role of the prefrontal cortex in behavioral and neural correlates of cognition in schizophrenia. Behavioral, electrophysiological (EEG) and neuroimaging measures will be used to …
Safety Tolerability and Pharmacokinetics of a Recombinant Humanized mAb Specific to B-and T-Lymphocyte Attenuator (BTLA) for Injection in Subjects With Advanced Malignancies
A 3-part (dose-escalation, dose-expansion and cohort-expansion) phase I clinical study of JS004 in subjects with advanced solid malignancies in China for the first time, to evaluate the safety, tolerability, PK, immunogenicity, antitumor activity and biomarkers of JS004, define the MTD and RP2D. A cycle is 21 days (3 weeks) which …
A Study of HMPL-306 in Patients With IDH1 and/or IDH2 Mutation of Relapsed/Refractory Myeloid Leukemia/Neoplasms
Phase I, multicenter study to evaluate the safety, pharmacokinetics, pharmacodynamics and efficacy of HMPL-306 in Patients of Relapsed/Refractory Myeloid Leukemia/Neoplasms with IDH1 and/or IDH2 Mutation.
Morphological Parameters of In-stent RESTenosis Assessed and Identified by OCT
The statistical risk of intrastent stenosis has fallen considerably with the emergence of latest generation coated stents (drug-eluting stents: DES). The number and clinical lifespan of stents implanted over the last twenty-five years, however, explain the fact that restenosis remains a not unusual clinical problem which is expressed as a …
Consumer Perceptions of Milk Beverages
The objectives of this study are to: Investigate and describe perceptions of nutrient content, including calories, of plant-based milks and dairy milks without food labels (ie., no Ingredient or Nutrition Facts label) and how this impacts consumption choice. Determine understanding of nutrient content, including calories, of plant-based milks and dairy …
Baby Item Learning and Development Study
The goal of this study is to experimentally test whether baby items can promote healthy infant development.
Glycogen Metabolism in Children
It is not fully understood in children how much of hepatic and muscle glycogen is used during a night and how they are replenished after a breakfast. This study aims to analyze the glycogen metabolism before and after an overnight sleep as well as after a breakfast in children between …
Nivolumab in Combination With Temozolomide and Radiotherapy in Children and Adolescents With Newly Diagnosed High-grade Glioma
Multicenter, open label, prospective study including successively a phase I trial and then a phase II trial Phase I : Open label, non-randomized, safety run study in nine patients. In case of safety issue a -1 dose level will be tested. Phase II : Open label, non randomized, efficacy study …
BS01 in Patients With Retinitis Pigmentosa
Non-randomized, open label, Phase 1/2 dose escalation study of BS01, a non-replicating, rep/cap-deleted, recombinant adeno-associated virus vector expressing an enhanced light-sensitive channelrhodopsin gene (ChronosFP).
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease.
This study aims to determine if one of three low doses of lithium therapy for 6 months can engage one or more blood-based therapeutic targets implicated in Parkinson's disease (PD) pathophysiology. Results of this study will help to determine if lithium therapy is worthwhile to further investigate as a potential …
