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Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19

Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19

Recruiting
18-80 years
All
Phase N/A

Overview

Ivermectin which is an FDA-approved broad spectrum anti-parasitic agent, has also anti-viral activity. In vitro study have shown its activity against SARS-CoV-2, however its clinical effect on patients with COVID-19 never been tested.

In this RCT we would like to evaluate the effect of Ivermectin on reduction of viral shedding among mild to moderate COVID-19 patients, and in shortening the symptom resolution time.

Eligibility

Inclusion Criteria:

Participants eligible for inclusion will include non-pregnant adult (>18 years old) with molecular confirmation of COVID-19. [Participants will be eligible in a period of no longer than 72 hours after exposure].

Exclusion Criteria:

  • Severe infection ( defined as need for invasive or non-invasive ventilator support, ECMO or shock requiring vasopressor support).
  • Weight below 40Kg or above 100Kg
  • Unable to take oral medication
  • Known allergy to the drugs
  • Pregnancy or breast feeding
  • Participating in another RCT for treatment of COVID-19.

Study details
    Covid 19

NCT04429711

Sheba Medical Center

16 February 2024

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