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Effect of Progesterone Therapy on Traumatic Subarachinoid Haemorrhage on Clinical Outcome and Resistive Vasculer Indices of Middle Cerebral Artery Transcranial Doppler

Effect of Progesterone Therapy on Traumatic Subarachinoid Haemorrhage on Clinical Outcome and Resistive Vasculer Indices of Middle Cerebral Artery Transcranial Doppler

Recruiting
20-65 years
All
Phase N/A

Overview

Traumatic subarachinoid hemorrhage is associated with serious complications related to mortality . Delayed neuronal ischemia and rebleeding are most common and serious. Progesterone can delay both .

Description

Progesterone is an neurosteroid that can help integrity of blood brain barrier . Traumatic subarachinoid hemorrhage disrupts this blood brain barrier facilitating post traumatic vasospasm and neuronal ischemia. Transcranial doppler can detect cerebral vasoconstriction through resistive vasculer indices

Eligibility

Inclusion Criteria:

  • Traumatic subarachinoid hemorrhage

Exclusion Criteria:

  • History of malignency
  • History of cerebrovasculer stroke
  • Morbid obese

Study details
    Brain Injury
    Brain Injury
    Brain Injuries
    Traumatic

NCT04426487

Minia University

16 February 2024

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