Overview
Background
The current SARS-CoV-2 pandemic presents a serious challenge to public health. Some people who are infected with SARS-CoV-2 have mild symptoms or none at all. But others develop severe symptoms, like pneumonia or organ failure. Researchers think that people s genes might play a role in how sick they get. Researchers want to look at the genes of people who have tested positive for COVID-19 to learn more.
ObjectiveTo learn more about COVID-19 by studying the DNA of people who have tested positive for it, and to share data as fast as possible with other qualified researchers who are also trying to learn more about COVID-19.
EligibilityPeople ages 3 years and older who have tested positive for COVID-19 and are being treated at the NIH Clinical Center or have tested positive through the Occupational Medical Service
DesignParticipants will complete a questionnaire about their health history and COVID-19 symptoms.
Participants will give a blood sample. It will be about 2 tablespoons of blood. Researchers will use this blood sample to study the participant s DNA.
The data about participants genes will be stored in a large database. The database will be shared with other qualified researchers who are trying to learn about COVID-19. Participants names and other personal details will not be shared. Instead, the data will be labeled with a code.
Participants may be contacted by study team members for up to a year after they give their blood sample.
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Description
The current SARS-CoV-2 pandemic presents a serious challenge to public health. Individuals infected with SARS-CoV-2 experience extremes in symptomatology ranging from a complete lack of symptoms to rapidly worsening end-stage pulmonary disease. The explanatory mechanism underlying susceptibility to severe disease remains unknown. We hypothesize that underlying genetic factors are at least partially explanatory. We aim to employ a phenotypic extremes approach to rapidly ascertain severely and mildly affected COVID-19 patients for genomic interrogation to identify germline and somatic variants that may play a role in host susceptibility to disease to correlate those phenotypic extremes with genetic variants. We will employ both a rare and common variant approach, using both genome sequencing and SNP chip analysis and B and T cell repertoire interrogation.
Eligibility
- INCLUSION CRITERIA
- FOR Cohort 1 (Existing NIH Clinical Center Patient/Participants invited to participate by their NIH study team) and Cohort 2 (Individuals recruited through NIH Occupational Medicine Services (OMS) invited to participate by OMS)
- Positive test for SARS-CoV-2 virus infection
- Weight greater than or equal to 10 kg
- Age greater than or equal to 3 years old
EXCLUSION CRITERIA:
-Individuals invited to participate for whom we cannot consent for participation in a language offered by our existing interpretation service.