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A Study to Evaluate the Safety Pharmacokinetics and Activity of GDC-6036 in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

A Study to Evaluate the Safety Pharmacokinetics and Activity of GDC-6036 in Patients With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

Recruiting
18 years and older
All
Phase 1

Overview

This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.

Eligibility

Inclusion Criteria:

  • Histologically documented advanced or metastatic solid tumor with KRAS G12C mutation.

Exclusion Criteria:

  • Active brain metastases
  • Malabsorption or other condition that interferes with enteral absorption
  • Clinically significant cardiovascular dysfunction or liver disease

Study details
    Non-Small Cell Lung Cancer
    Non-Small Cell Lung Cancer
    Colorectal Cancer
    Colorectal Cancer
    Rectal disorder
    Advanced Solid Tumors

NCT04449874

Genentech, Inc.

16 February 2024

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