Overview
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose for children. The primary objective of this study is to evaluate the PK of understudied drugs currently being administered to children per SOC as prescribed by their treating provider.
Eligibility
Inclusion Criteria:
1 (a) Participant is < 21 years of age and is receiving understudied drugs of interest (DOIs) per standard of care (SOC) as prescribed by their treating provider OR (b) Participant is NOT receiving one or more of the study drugs of interest but is SARS-CoV-2 positive within 60 days prior to enrollment
2. Parent/ Legal Guardian/ Adult Participant can understand the consent process and is willing to provide informed consent/HIPAA
Exclusion Criteria:
- Participant has a known pregnancy
For participants receiving one or more of the study drugs of interest at the time of enrollment, DOI administration or PK sampling:
(Refer to DOI specific appendices for details on enrollment cohort specifications)
2. Has had intermittent dialysis within previous 24 hours
3. Has had a kidney transplant within previous 30 days
4. Has had a liver transplant within previous 1 year
5. Has had a stem cell transplant within previous 1 year
6. Has had therapeutic hypothermia within previous 24 hours
7. Has had plasmapheresis within the previous 24 hours
8. Has a Ventricular Assist Device
9. Has any condition which would make the participant, in the opinion of the investigator, unsuitable for the study