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A Study to Evaluate the Safety Tolerability Pharmacokinetics and Pharmacodynamics of DNL343 in Healthy Volunteers

A Study to Evaluate the Safety Tolerability Pharmacokinetics and Pharmacodynamics of DNL343 in Healthy Volunteers

Recruiting
18-50 years
All
Phase 1

Overview

This is a Phase 1 study carried out at a single site in 88 healthy male subjects and healthy female subjects of non childbearing potential to investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of DNL343.

Eligibility

Key Inclusion Criteria:

  • Women of non-childbearing potential and men; aged 18-50 years, inclusive
  • BMI 18-32 kg/m, inclusive, and body weight of at least 50 kg

Key Exclusion Criteria:

  • History of clinically significant neurologic, psychiatric, endocrine, pulmonary, cardiovascular, gastrointestinal, hepatic, pancreatic, renal, metabolic, hematologic, immunologic, or allergic disease, or other major disorders

Study details
    Healthy Volunteers

NCT04268784

Denali Therapeutics Inc.

16 February 2024

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