Overview
Combinations Natural Killer Cell (NK) With chemotherapy treatment may enhance the immune response and stop cancer cells from growing.
Description
Patients in group A will receive 4 cycles of NK treatments within 8 months. Patients in group B will have no immunotherapy. Chemotherapy are available in both groups.The investigators want to evaluate the efficacy of combination of NK with chemotherapy in patients with treatment-refractory solid tumors
Eligibility
Inclusion Criteria:
- Patients with treatment-refractory advanced solid cancer can not accept operation;
- Age 10 to 90 years;
- Eastern Cooperative Oncology Group (ECOG) score 2 points;
- estimate survival > 3 months;
- Blood White Blood Cell(WBC) 4109/L, Hb 100g/L, Platelet Count (PLT) 80109/L; Alanine amino transferase (ALT) and aspartate amino transferase (AST) 2 times of normal upper value; Serum Cr 2 normal upper value;
- Without any other malignant disease;
- With more than one scalable lesions;
- Patients Voluntary attempt, and informed consent;
- Women of child-bearing potential must have a negative pregnancy test because of the potentially dangerous effects of the preparative chemotherapy on the fetus.
Exclusion Criteria:
- Patients who do not conform to the inclusion criteria;
- Patients with uncontrolled infection; underlying disease that was severe or life-threatening (such as uncontrolled brain metastasis );
- Patients who were pregnant or lactating;
- ECOG perform status 2;4.
- Other situations that the researchers considered unsuitable for this study (such as mental illness, drug abuse, etc.)