This study investigates the potential link between potassium channels and migraine. Potassium channels are pathways that help control electrical signals in the body, and this study aims to find out if they play a role in the development of migraines. The study will focus on a molecule called maxipost, which affects blood vessels and may be connected to headaches and migraines.

Participants will receive an infusion of maxipost to observe its effects on headaches and migraines. The study will include both healthy volunteers and migraine patients to compare the effects. This will help researchers better understand how potassium channels might influence migraine symptoms.

• Who can participate: Adults aged 18 to 60 years, weighing between 50 and 90 kg, are eligible. Migraine patients should not have aura and must meet international headache criteria. Women of childbearing potential must use contraception.
• Study details: Participants will receive an infusion of the investigational medication maxipost, a vasoactive molecule. The study will compare the effects on healthy volunteers and migraine patients. Maxipost works through the BKCa channel pathway (a type of potassium channel that affects blood vessel function), which may be related to migraine development.