This study investigates the treatment of diabetic foot infections (DFI), specifically focusing on the optimal duration of antibiotic therapy for diabetic toe osteomyelitis and soft tissue infections. Diabetic foot infections are common and can lead to serious health issues, often requiring careful management of antibiotic use to prevent resistance and reduce side effects. The study aims to compare the effectiveness of different durations of antibiotic treatment following surgical debridement, where dead or infected tissue is removed.

Participants will be randomized into study arms to receive either a shorter or longer course of antibiotics. For diabetic toe osteomyelitis, participants will be assigned to a 3-week or 6-week treatment arm, while for soft tissue infections, the duration will range between 10 to 20 days. The study will monitor the outcomes to determine the most effective treatment duration, with final assessments conducted approximately 60 days after treatment completion.

• Who can participate: Adults aged 18 or older with diabetes mellitus and diabetic foot infections can participate. Key criteria include undergoing surgical intervention to remove necrotic tissue and having osteomyelitis limited to bone contact or cortical lesions visible on X-ray.
• Study details: Participants will be divided into study arms to receive different durations of antibiotic treatment following surgical debridement. A placebo will not be used in this study.