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Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73

Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73

Recruiting
18-90 years
All
Phase 0
  • Simplified description (AI rewritten)
  • Technical description (Original)

The boom in radiopharmaceuticals continues to persist, including their driving effects in the field of immunotherapy. CD73 (ecto-5'-nucleotidase), a key purine metabolic enzyme, catalyzes the conversion of extracellular nucleotides to adenosine, promoting tumor immune evasion and unfavorable clinical outcomes. Notably, CD73 is highly expressed in 74.3% of breast cancer cases, with its prevalence exceeding 45% in liver, gastric, colorectal, and ovarian cancers. As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. The present study aimed to evaluate the biodistribution, pharmacokinetics, and dosimetry of 68Ga-dPNE, and performed a head-to-head comparison with 18F-FDG PET/CT scans in patients with various cancers.

Study details
    Malignant Tumour

NCT06995976

First Affiliated Hospital of Fujian Medical University

8 August 2025

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