Overview
The goal of the study is to investigate the feasibility of enabling a second chance for breast conservation in patients with in-breast recurrences after a previous lumpectomy and RT, investigators propose to test partial breast irradiation with the target volume encompassing the entire surgical bed with 1.0-1.5 cm margins.
Description
Patients will be treated with the fractionation of 30 Gy in 5 fractions over 1-2 weeks, which is the accelerated fractionation scheme of choice for Radiation Therapy (RT) nave patients at New York Presbyterian using EBRT.
The main aim of the study is to evaluate the rate of early grade 3 toxicities with this approach.
Eligibility
Inclusion Criteria:
- Isolated ipsilateral unifocal breast lesions
- Limited size (< 2-3 cm) without evidence of skin involvement
- Histologically proven invasive breast carcinoma
- Negative histologic margins of resection
- Patients with 0 to 3 positive axillary lymph nodes without extracapsular extension
- No synchronous distant metastases
- Age 50 years
- 24 months interval between initial breast conserving therapy (surgery and whole breast radiotherapy) and recurrence
- Patient preference
- Technical feasibility
- Every kind of systemic therapy is allowed
- Informed consent for clinical and research purposes signed
Exclusion Criteria:
- Regional recurrences (axillary, supraclavicular)
- Positive histologic margins at resection
- Metastatic disease
- Poor cosmesis from previous surgery and RT
- Previous breast RT performed with IORT, brachytherapy or previous partial breast treatment
- Extensive Intraductal Component