Overview
The primary objective of this study is to assess stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia. The secondary objectives are (1) to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia; to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with non-myotonic neuromuscular disorders, (3) assess correlations between to compare result values for stiffness, muscle tone, relaxation periods and elasticity with clinical muscle function tests, measured by clinical evaluation (MRC-scale) and the 6-minute walk test; (4) assess correlations between subcutaneous fat and muscle thickness and echogenicity, measured by muscle ultrasound and result values for stiffness, muscle tone, relaxation periods and elasticity.
Eligibility
Inclusion Criteria:
For Patients:
- 18 years of age
- Confirmed neuromuscular disease
- written consent
- able and willing to perform study prodcedures
For healthy volunteers:
- age 18 years of age
- written informed consent
- no clinical sign for neuromuscular disorders
Exclusion Criteria:
- Severe comorbidities
- Patient is participating in another clinical study using investigational treatment
- Patient cannot perform required muscle function tests
- the patient, in the opinion of the investigator, is unable to adhere to the requirements of the study