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Correlation Between Oxidative Stress Status and COVID-19 Severity

Correlation Between Oxidative Stress Status and COVID-19 Severity

Recruiting
18 years and older
All
Phase N/A

Overview

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement.

Description

Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement. Demographic and lab data of 60 COVID-19 confirmed positive cases gathered .These patients divided in to two arms: 1- severe COVID-19 which were intubated or admitted in intensive care unit due to severe hypoxia 2- non-severe COVID-19 patients which were not hypoxic and admitted in ward with no need to invasive oxygenation. All patients had positive RT-PCR positive nasopharyngeal swab results for COVID-19 or Lung CT scan compatible with COVID-19. Malondialdehyde(MDA) , Biopterin, Neopterin, SOD, Glutathione levels would be checked by ELISA tests and compared between these two groups and healthy controls.

Eligibility

Inclusion Criteria:

  • more than 18 years old
  • positive RT-PCR COVID-19
  • compatible lung CT with COVID-19

Exclusion Criteria:

  • not signing informed consent
  • using antioxidants
  • using statins

Study details
    Physiological Stress
    Stress
    Oxidative Stress
    Stress

NCT04375137

Shahid Beheshti University of Medical Sciences

5 August 2020

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