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Switch of Renin-Angiotensin System Inhibitors in Patients With Covid-19

Switch of Renin-Angiotensin System Inhibitors in Patients With Covid-19

Recruiting
18-80 years
All
Phase 2/3

Overview

The SWITCH-COVID trial will randomize patients with COVID-19 that are currently using renin-angiotensin system inhibitors for treating hypertension to maintain the therapy during in-hospital stay or switch the therapy to other antihypertensive classes.

Description

Patients eligible for the study, after signing informed consent will be randomized 1:1 for maintenance of renin-angiotensin system inhibitors or switching the antihypertensive therapy for other classes according to a pre-specified protocol.

Patients are going to be followed during hospital stay for evaluation of clinical endpoints. Also blood and urine samples will be acquired for evaluation of renin-angiotensin system activation.

Eligibility

Inclusion Criteria:

  • Hypertension in use of renin-angiotensin system inhibitors
  • Confirmed COVID-19 infection by rt-PCR, serology tests or typical clinical presentation and chest CT.
  • Symptoms onset < 96h
  • Need for hospitalization

Exclusion Criteria:

  • Heart failure
  • Previous cerebrovascular disease
  • Previous myocardial infarction
  • Blood pressure > 180 x 100 mmHg
  • Need for 3 or more anti-hypertensive classes
  • Use os spironolactone
  • Severe pulmonary disease
  • Contraindication for using other anti-hypertensive classes (calcium channel blockers, hydralazine, diuretics or nitrates)

Study details
    COVID19
    Angiotensin II Receptor Antagonist Adverse Reaction

NCT04493359

University of Sao Paulo

16 February 2024

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