Overview
This observational study will compare the clinical value of weight-bearing CT arthrography (WBCTa) with that for MRI in evaluating meniscal and cartilage lesions of the knee joint. The MRI Osteoarthritis Knee Score (MOAKS) and modified MOAKS for WBCTa will be used to compare findings between MRI and WBCTa of the knee.
The study hypothesis is that meniscal and cartilage lesions may be missed by non-weight-bearing MRI, but detected by WBCTa.
Description
Study Objectives: The goal of this study is to assess the clinical value and inter-rater reliability of WBCTa in evaluating meniscal and cartilage lesions and compare with detection of these lesions on contemporaneous MRI.
Study Type and Design: This cross-sectional, observational study will compare WBCTa with MRI to evaluate rate of detection of meniscal and cartilage lesions. The inter-rater reliability of WBCTa readings also will be assessed.
Eligibility
Inclusion Criteria:
- Male or female over 18 years of age with a knee MRI acquired in the previous 10 days to evaluate for suspected meniscal or cartilage pathology.
- Body mass index (BMI) 45 kg/m2
- Ability to stand with support without moving for at least 2 minutes.
Exclusion Criteria:
- End stage kidney disease
- Allergic to iodinated contrast material.
- Pregnancy
- Skin breakdown or rash at the knee joint which would prevent injection of the contrast.
- Any clinically significant degree of cognitive impairment or other condition, finding, or psychiatric illness at screening which, in the opinion of the investigator, affects their ability to ambulate to a sufficient degree and could compromise patient safety or interfere with the assessment of the safety of the study injection.